FEBS MPST 2013

FEBS Journal Special Issue

Proteoglycans: signaling, targeting and therapeutics

Volume 280, Issue 10, May 2013, Pages i–iii, 2119–2534

Nikos K. Karamanos and Robert J. Linhardt

http://onlinelibrary.wiley.com/doi/10.1111/febs.2013.280.issue-10/issuetoc

This special issue of FEBS Journal contains 31 review and primary research articles reflecting the advancements covered at the 2012 Proteoglycans Gordon Research Conference and novel aspects from experts in the field. It is mainly focused on current status of the extracellular and cell surface proteoglycans’ regulatory roles in cell signaling, molecular targeting, engineering attempts and potential therapeutic approaches.

Extracellular Matrix: Pathobiology and Signaling

Ed. by Nikos Karamanos,

ISBN: 978-3-11-025877-6

http://www.degruyter.com/view/product/174386

• Comprehensive treatment of the extracellular matrix with special focus on matrix pathobiology and cell molecular biology
• Role of the extracellular matrix in health and disease with outlook for biotechnological and pharmacological applications
• High quality color illustrations

Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting.
It will provide an introduction to the extracellular matrix and detailed sections and chapters on:

• Importance of extracellular matrix in health and disease
• Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin)
• Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system)
• Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer,  inflammation and metabolic control)
• Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases)
• Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR).
• Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics).

"The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications."

Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden

Thanks to the contribution of the invited speakers of the FEBS-MPST Advanced Lecture Courses, the following MiniReview Series have been published in FEBS J (www.febsjournal.org):

1^st MiniReview Series:Proteoglycans in health and disease: emerging concepts and future directions
Coordinated by Renato V. Iozzo and Nikos Karamanos, http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2010.07796.x/pdf

Articles

1. - Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans
Renato V. Iozzo and Liliana Schaefer http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2010.07797.x/pdf

2. - Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis
Uri Barash, Victoria Cohen-Kaplan, Ilana Dowek, Ralph D. Sanderson, Neta Ilan and Israel Vlodavsky
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2010.07799.x/pdf

3. - Proteoglycans in health and disease: the multiple roles of syndecan shedding
Tina Manon-Jensen, Yoshifumi Itoh and John R. Couchman
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2010.07798.x/pdf

4. - Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting
Achilleas D. Theocharis, Spyridon S. Skandalis, George N. Tzanakakis and Nikos K. Karamanos
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2010.07800.x/pdf

2^nd MiniReview Series: Metalloproteinases in health and disease: challenges and the future prospects

Coordinated by Hideaki Nagase and Nikos Karamanos, http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2010.07917.x/pdf

Articles

1. Regulation of matrix metalloproteinase activity in health and disease

Elin Hadler-Olsen, Bodil Fadnes, Ingebrigt Sylte, Lars Uhlin-Hansen and Jan-Olof Winberg, http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2010.07920.x/pdf

2. Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

Chrisostomi Gialeli, Achilleas D. Theocharis and Nikos K. Karamanos, http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2010.07919.x/pdf

3. Localizing matrix metalloproteinase activities in the pericellular environment

Gillian Murphy and Hideaki Nagase, http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2010.07918.x/pdf

3^rd MiniReview Series: Regulatory roles of hyaluronan in health and disease

Coordinated by Vincent Hascall and Nikos Karamanos, 277 (9) 2011 1411-1443

For more details see the attachment.

Attachments:

FEBSJournalSeriesonHyaluronan2011.pdf

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